Inclusion of a compound does not constitute endorsement. Information sourced from published research and regulatory filings.

Kisspeptin-10

Cat 2 → Pending Cat 1

Longevity & Immune · Research peptide (multiple suppliers)

Decapeptide fragment of kisspeptin researched for reproductive hormone axis regulation. Not FDA-approved for any indication.

About

Mechanism

Decapeptide fragment of kisspeptin that activates KISS1R (GPR54) in hypothalamic GnRH neurons. Potently stimulates LH and FSH secretion, serving as a key regulator of the reproductive hormone axis.

Half-Life

Approximately 4 minutes (IV), 27 minutes (SC)

Route

subcutaneous

Frequency

Single dose (weight-based: 1-10 mcg/kg)

Clinical Dosing

75-750 mcgsingle dose (weight-based: 1-10 mcg/kg)

Not FDA-approved. Investigational use in reproductive endocrinology. Currently FDA Category 2 (restricted). Pending return to Category 1.

Weight-based dosing: 1-10 mcg/kg (typically 75-750 mcg total for adults). Extrapolated from early human studies and community protocols. No large-scale clinical trials.

Regulatory Status

FDA Category

Research peptide (FDA Category 2)

Reclassification

pending

Date Restricted

2023-09-29

Announced Return

2026-02-27

Status based on publicly available FDA communications. Verify at FDA.gov for authoritative guidance.

View full regulatory timeline →

Titration Protocols

Research Protocol

Source: Dhillo et al., Journal of Clinical Endocrinology & Metabolism, 2005

Dose	Duration	Draw (1 mg vial in 2mL)	Notes
1 mcg	Maintenance	0.00 mL (< 1 units)	Single SC dose (research); dose varies by protocol

Available Vial Sizes

1 mg

1 mg vial

5 mg

5 mg vial

Citations

[1]Kisspeptin-54 Stimulates the Hypothalamic-Pituitary-Gonadal Axis in Human Males. Journal of Clinical Endocrinology & Metabolism, 90(12), 6609-6615. Link(Reviewed: 2026-02-27)